Article
Nuclear lamins, diseases and aging.
Current opinion in cell biology - 1 Jun 2006
Mattout Anna, Dechat Thomas, Adam Stephen A, Goldman Robert D, Gruenbaum Yosef
Abstract excerpt
Nuclear lamins are type V intermediate filament proteins. They are the major building blocks of the peripheral nuclear lamina, a complex meshwork of proteins underlying the inner nuclear membrane. In addition to providing nuclear shape and mechanical stability, they are required for chromatin organization, transcription regulation, DNA replication, nuclear assembly and nuclear positioning. Over the past few...
Topics
- Aging
- Amino Acid Sequence
- Animals
- Cell Nucleus
- Genetic Diseases, Inborn
- Humans
- Intermediate Filament Proteins
- Lamin Type A
- Lamins
- Models, Biological
- Models, Molecular
- Molecular Sequence Data