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Article

Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Jul 2016

Spiller Krista J, Cheung Claudia J, Restrepo Clark R, Kwong Linda K, Stieber Anna M, Trojanowski John Q, Lee Virginia M-Y

Abstract excerpt

UNLABELLED: Motor neurons (MNs) are the neuronal class that is principally affected in amyotrophic lateral sclerosis (ALS), but it is widely known that individual motor pools do not succumb to degeneration simultaneously. Because >90% of ALS patients have an accumulation of cytoplasmic TDP-43 aggregates in postmortem brain and spinal cord (SC), it has been suggested that these inclusions in a given population may...

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Identifiers

PMID: 27445147
DOI: 10.1523/JNEUROSCI.1457-16.2016
PMCID: PMC6705561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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