Article
Gene expression variations in microsatellite stable and unstable colon cancer cells.
The Journal of surgical research - 1 May 2012
Duldulao Marjun P, Lee Wendy, Le Maithao, Chen Zhenbin, Li Wenyan, Wang Jinhui, Gao Harry, Li Haiquing, Kim Joseph, Garcia-Aguilar Julio
Abstract excerpt
BACKGROUND: Microsatellite instability (MSI) is a marker of chemoresistance, but it is associated with improved survival compared with microsatellite-stable (MSS) colon cancers. We hypothesized that MSI tumors overexpress chemoresistance-associated genes and underexpress DNA damage/repair genes. We used ultra high-throughput sequencing (UHTS) to assess the expression of representative genes in MSI and MSS colon...
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