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Article

Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly.

Cell - 5 Aug 2011

Zhang Rundong, So Byung Ran, Li Pilong, Yong Jeongsik, Glisovic Tina, Wan Lili, Dreyfuss Gideon

Abstract excerpt

The SMN complex mediates the assembly of heptameric Sm protein rings on small nuclear RNAs (snRNAs), which are essential for snRNP function. Specific Sm core assembly depends on Sm proteins and snRNA recognition by SMN/Gemin2- and Gemin5-containing subunits, respectively. The mechanism by which the Sm proteins are gathered while preventing illicit Sm assembly on non-snRNAs is unknown. Here, we describe the 2.5 Å...

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Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscular Atrophy, Spinal

Share to Nerve Tissue Proteins

Share to Ribonucleoproteins, Small Nuclear

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Source

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Identifiers

PMID: 21816274
DOI: 10.1016/j.cell.2011.06.043
PMCID: PMC3160754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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