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Article

Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization.

Molecular genetics and metabolism - 1 Jul 2008

Li Fang, Feng Qiping, Lee Candace, Wang Shuzhan, Pelleymounter Linda L, Moon Irene, Eckloff Bruce W, Wieben Eric D, Schaid Daniel J, Yee Vivien, Weinshilboum Richard M

Abstract excerpt

Betaine-homocysteine methyltransferase (BHMT) catalyzes the remethylation of homocysteine. BHMT2 encodes a protein 73% identical in amino acid sequence to BHMT, but the function of BHMT2 remains unclear. We set out to identify and functionally characterize common genetic variation in BHMT and BHMT2. Specifically, we sequenced exons, exon-intron splice junctions and the 5'-flanking regions (5'-FRs) of BHMT and...

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Identifiers

PMID: 18457970
DOI: 10.1016/j.ymgme.2008.03.013
PMCID: PMC2515933

Genes

BHMT
BHMT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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