Progression of liver fibrosis in HIV/HCV genotype 1 co-infected patients is related to the T allele of the rs12979860 polymorphism of the IL28B gene.

doi:10.1186/2047-783x-16-8-335

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Article

Progression of liver fibrosis in HIV/HCV genotype 1 co-infected patients is related to the T allele of the rs12979860 polymorphism of the IL28B gene.

European journal of medical research - 8 Aug 2011

Lutz P, Wasmuth J-C, Nischalke H-D, Vidovic N, Grünhage F, Lammert F, Oldenburg J, Rockstroh J K, Sauerbruch T, Spengler Ulrich

Abstract excerpt

OBJECTIVE: HIV/HCV co-infection is characterised by accelerated progression of liver disease. Recently, the rs12979860 C/T polymorphism in the IL28B gene has been linked to progression towards cirrhosis in HCV mono-infected patients and to treatment response of HCV-infection in HIV/HCV co-infected patients. Our aim was to clarify by non-invasive techniques if this polymorphism affects fibrosis progression in...

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PMID: 21813376
DOI: 10.1186/2047-783x-16-8-335
PMCID: PMC3351985

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