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Article

Implications of the prion-related Q/N domains in TDP-43 and FUS.

Prion - 1 Jan 2000

Udan Maria, Baloh Robert H

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are clinically overlapping neurodegenerative disorders whose pathophysiology remains incompletely understood. ALS initiates in a discrete location, and typically progresses in a pattern consistent with spread of the degenerative process to involve neighboring regions of the motor system, although the basis of the apparent "spread"...

Topics

Amyotrophic Lateral Sclerosis
Animals
Asparagine
DNA-Binding Proteins
Frontotemporal Lobar Degeneration
Glutamine
Humans
Models, Genetic
Mutation
Neurons
Prions
Protein Structure, Tertiary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Binding Protein FUS

Source

Open in PubMed Open full text

Identifiers

PMID: 21135580
DOI: 10.4161/pri.5.1.14265
PMCID: PMC3037998

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Implications of the prion-related Q/N domains in TDP-43 and FUS.PMID 21135580Read ↗

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