Article
Implications of the prion-related Q/N domains in TDP-43 and FUS.
Prion - 1 Jan 2000
Udan Maria, Baloh Robert H
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are clinically overlapping neurodegenerative disorders whose pathophysiology remains incompletely understood. ALS initiates in a discrete location, and typically progresses in a pattern consistent with spread of the degenerative process to involve neighboring regions of the motor system, although the basis of the apparent "spread"...
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