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Article

Reexamining a proposal: thymidylate synthase 5'-untranslated region as a regulator of translation efficiency.

Cancer biology & therapy - 15 Oct 2011

Ghosh Soma, Winter Jordan M, Patel Kalpesh, Kern Scott E

Abstract excerpt

The DNA replicative gene, thymidylate synthase (TYMS), is inhibited upon treatment with the anticancer drug 5-fluorouracil (5FU). TYMS has 28-bp tandem repeat sequences or VNTR (variable numbers of tandem repeats) in the 5'-untranslated region (5'-UTR). The number of these repeats is variable in any given population, but the most prevalent are double (2R) and triple (3R) repeat sequences. A single G/C nucleotide...

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Source

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Identifiers

PMID: 21811101
DOI: 10.4161/cbt.12.8.16867
PMCID: PMC3218528

Genes

TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Reexamining a proposal: thymidylate synthase 5'-untranslated region as a regulator of translation efficiency.PMID 21811101Read ↗

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Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancerSemantic proximity Read ↗

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