Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil: Is it time to move forward?

1 Jul 2008

Abstract excerpt

Thymidylate synthase is a target of 5-fluoruracil, a pyrimidine analog used to treat gastrointestinal and other cancers. The 5-fluorouracil metabolite, fluoro-deoxyuridine monophosphate, forms a ternary complex with thymidylate synthase and 5,10-methylene tetrahydrofolate. The purpose of this study was to evaluate the time-honored connection between thymidylate synthase and 5-fluorouracil. From our literature...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Cancer Treatments and Studies
Share to Gastric Cancer Management and Outcomes
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18443433
DOI: 10.4161/cbt.7.7.6181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil: Is it time to move forward?PMID 18443433Read ↗

Thymidylate Synthase: A Target for Combination Therapy and Determinant of Chemotherapeutic Response in Colorectal CancerSemantic proximity Read ↗

Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.Semantic proximity Read ↗

The Role of Thymidylate Synthase as a Molecular BiomarkerSemantic proximity Read ↗

Novel opportunities for thymidylate metabolism as a therapeutic targetSemantic proximity Read ↗

Thymidylate synthase inhibitors for non-small cell lung cancerSemantic proximity Read ↗

Review of 5-FU resistance mechanisms in colorectal cancer: clinical significance of attenuated on-target effectsSemantic proximity Read ↗

Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancerSemantic proximity Read ↗

miR-192/miR-215 Influence 5-Fluorouracil Resistance through Cell Cycle-Mediated Mechanisms Complementary to Its Post-transcriptional Thymidilate Synthase RegulationSemantic proximity Read ↗

<i>Thymidylate synthase</i>gene variations: predictive and prognostic markersSemantic proximity Read ↗

Polymorphism of thymidylate synthase gene and chemosensitivity of 5-fluorouracil regimen in metastatic gastrointestinal cancer.Semantic proximity Read ↗

Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of actionSemantic proximity Read ↗

Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.