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Article

NMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene.

BMC cancer - 2 Aug 2011

Mattila Henna, Schindler Martin, Isotalo Jarkko, Ikonen Tarja, Vihinen Mauno, Oja Hannu, Tammela Teuvo L J, Wahlfors Tiina, Schleutker Johanna

Abstract excerpt

BACKGROUND: Several predisposition loci for hereditary prostate cancer (HPC) have been suggested, including HPCX1 at Xq27-q28, but due to the complex structure of the region, the susceptibility gene has not yet been identified. METHODS: In this study, nonsense-mediated mRNA decay (NMD) inhibition was used for the discovery of truncating mutations. Six prostate cancer (PC) patients and their healthy brothers were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21810217
DOI: 10.1186/1471-2407-11-327
PMCID: PMC3162583

Genes

MAGEC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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