Article
Killer-cell immunoglobulin-like receptor genotyping and HLA killer-cell immunoglobulin-like receptor-ligand identification by real-time polymerase chain reaction.
Tissue antigens - 1 Sept 2011
Hong H A, Loubser A S, de Assis Rosa D, Naranbhai V, Carr W, Paximadis M, Lewis D A, Tiemessen C T, Gray C M
Abstract excerpt
The effector function of natural killer (NK) cells is modulated by surface expression of a range of killer-cell immunoglobulin-like receptors (KIRs) that interact with human leukocyte antigen (HLA) class I ligands. We describe the use of real-time polymerase chain reaction (PCR) assays that allow easy and quick detection of 16 KIR genes and the presence/absence of KIR-ligands based on allelic discrimination at...
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