Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyp26 enzymes function in endoderm to regulate pancreatic field size.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2009

Kinkel Mary D, Sefton Elizabeth M, Kikuchi Yutaka, Mizoguchi Takamasa, Ward Andrea B, Prince Victoria E

Abstract excerpt

The control of organ size and position relies, at least in part, upon appropriate regulation of the signals that specify organ progenitor fields. Pancreatic cell fates are specified by retinoic acid (RA), and proper size and localization of the pancreatic field are dependent on tight control of RA signaling. Here we show that the RA-degrading Cyp26 enzymes play a critical role in defining the normal anterior...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Endoderm

Share to In Situ Hybridization

Share to Pancreas

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19416885
DOI: 10.1073/pnas.0813108106
PMCID: PMC2683109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyp26 enzymes function in endoderm to regulate pancreatic field size.PMID 19416885Read ↗

Cdx4 is required in the endoderm to localize the pancreas and limit beta-cell number.Semantic proximity Read ↗

Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo.Semantic proximity Read ↗

Retinoic acid production, regulation and containment through Zic1, Pitx2c and Cyp26c1 control cranial placode specification.Semantic proximity Read ↗

Cyp26 Enzymes Facilitate Second Heart Field Progenitor Addition and Maintenance of Ventricular IntegritySemantic proximity Read ↗

Genetic deletion of<i>Cyp26b1</i>negatively impacts limb skeletogenesis by inhibiting chondrogenesisSemantic proximity Read ↗

Retinoic acid-metabolizing enzyme Cyp26a1 is essential for determining territories of hindbrain and spinal cord in zebrafish.Semantic proximity Read ↗

Organ-specific requirements for Hdac1 in liver and pancreas formation.Semantic proximity Read ↗

Retinoic acid-activated Ndrg1a represses Wnt/β-catenin signaling to allow Xenopus pancreas, oesophagus, stomach, and duodenum specification.Semantic proximity Read ↗

Endoderm Jagged induces liver and pancreas duct lineage in zebrafishSemantic proximity Read ↗

Human organoids reveal PTEN-driven mesendoderm specification via retinoic acid signaling suppressionSemantic proximity Read ↗

Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos.Semantic proximity Read ↗

FGF2 Specifies hESC-Derived Definitive Endoderm into Foregut/Midgut Cell Lineages in a Concentration-Dependent MannerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.