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Article

Retinoic acid and Cyp26b1 are critical regulators of osteogenesis in the axial skeleton.

Development (Cambridge, England) - 1 Nov 2008

Spoorendonk Kirsten M, Peterson-Maduro Josi, Renn Jörg, Trowe Torsten, Kranenbarg Sander, Winkler Christoph, Schulte-Merker Stefan

Abstract excerpt

Retinoic acid (RA) plays important roles in diverse biological processes ranging from germ cell specification to limb patterning. RA ultimately exerts its effect in the nucleus, but how RA levels are being generated and maintained locally is less clear. Here, we have analyzed the zebrafish stocksteif mutant, which exhibits severe over-ossification of the entire vertebral column. stocksteif encodes cyp26b1, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18927155
DOI: 10.1242/dev.024034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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