Article
DNA assay based on monolayer-barcoded nanoparticles for mass spectrometry in combination with magnetic microprobes.
Talanta - 15 Sept 2011
Qiu Fei, Gu Kai, Yang Bing, Ding Yibing, Jiang Dawei, Wu Yan, Huang Lequn Lee
Abstract excerpt
Mass spectrometry (MS) based methodology offers simple, fast and sensitive diagnosis. While it has become the predominate approach in biomolecular analysis, it has not been suitable for analyzing nucleic acid due to its low ionization efficiency. We report herein on a DNA assay based on monolayer-barcoded nanoparticles that were encoded with reporter mass molecules, which act as surrogate molecules for the...
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