Article
Recognition by the DNA repair system of DNA structural alterations induced by reversible drug-DNA interactions.
Anti-cancer drug design - 1 Feb 1990
Lambert B, Segal-Bendirdjian E, Esnault C, Le Pecq J B, Roques B P, Jones B, Yeung A T
Abstract excerpt
Ditercalinium (NSC 335153) was synthesized as a bifunctional DNA intercalator. It is made of two 7-H pyridocarbazole rings joined by a rigid bis-ethyl bispiperidine chain. It binds to DNA with high affinity and elicits anti-tumor activity on a variety of animal tumors. 1H n.m.r. studies of diterc...
Topics
- Animals
- Carbazoles
- DNA
- DNA Repair
- Drug Interactions
- Drug Screening Assays, Antitumor
- Endodeoxyribonucleases
- Escherichia coli
- Escherichia coli Proteins
- Intercalating Agents
- Leukemia L1210
- Mutation
- Nucleic Acid Conformation
- Structure-Activity Relationship
- Tumor Cells, Cultured