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Article

Mutation induced conformational changes in genomic DNA from cancerous K562 cells influence drug-DNA binding modes.

PloS one - 1 Jan 2014

Ghosh Debjani, Dey Subrata Kumar, Saha Chabita

Abstract excerpt

Normal human genomic DNA (N-DNA) and mutated DNA (M-DNA) from K562 leukemic cells show different thermodynamic properties and binding affinities on interaction with anticancer drugs; adriamycin (ADR) and daunomycin (DNM). Isothermal calorimetric thermograms representing titration of ADR/DNM with N-DNA and M-DNA on analysis best fitted with sequential model of four and three events respectively. From Raman...

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Identifiers

PMID: 24416304
DOI: 10.1371/journal.pone.0084880
PMCID: PMC3885628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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