Article
The roles of transcription and genotoxins underlying p53 mutagenesis in vivo.
Carcinogenesis - 1 Oct 2011
Wright Barbara E, Schmidt Karen H, Hunt Aaron T, Lodmell J Stephen, Minnick Michael F, Reschke Dennis K
Abstract excerpt
Transcription drives supercoiling which forms and stabilizes single-stranded (ss) DNA secondary structures with loops exposing G and C bases that are intrinsically mutable and vulnerable to non-enzymatic hydrolytic reactions. Since many studies in prokaryotes have shown direct correlations between the frequencies of transcription and mutation, we conducted in silico analyses using the computer program, mfg, which...
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