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Article

Hypermutable bases in the p53 cancer gene are at vulnerable positions in DNA secondary structures.

Cancer research - 15 Oct 2002

Wright Barbara E, Reimers Jacqueline M, Schmidt Karen H, Reschke Dennis K

Abstract excerpt

A DNA folding analysis indicates that the most hypermutable bases in exons 5, 7, and 8 of the p53 tumor suppressor gene are located immediately next to stems in stable DNA stem-loop structures. On the basis of the highest negative energy (-DeltaG) value of the structures containing each mutable bases and on the extent to which each base is unpaired during transcription, their relative mutabilities are calculated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12384517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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