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Article

Relationship of CYP2D6, CYP3A, POR, and ABCB1 genotypes with galantamine plasma concentrations.

Therapeutic drug monitoring - 1 Apr 2013

Noetzli Muriel, Guidi Monia, Ebbing Karsten, Eyer Stephan, Zumbach Serge, Giannakopoulos Panteleimon, von Gunten Armin, Csajka Chantal, Eap Chin B

Abstract excerpt

BACKGROUND: The frequently prescribed antidementia drug galantamine is extensively metabolized by the enzymes cytochrome P450 (CYP) 2D6 and CYP3A and is a substrate of the P-glycoprotein. We aimed to study the relationship between genetic variants influencing the activity of these enzymes and transporters with galantamine steady state plasma concentrations. METHODS: In this naturalistic cross-sectional study, 27...

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Source

Identifiers

PMID: 23503455
DOI: 10.1097/FTD.0b013e318282ff02

Genes

ABCB1
POR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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