Article
The voltage-dependent L-type Ca2+ (CaV1.2) channel C-terminus fragment is a bi-modal vasodilator.
The Journal of physiology - 15 Jun 2013
Bannister John P, Leo Marie Dennis, Narayanan Damodaran, Jangsangthong Wanchana, Nair Anitha, Evanson Kirk W, Pachuau Judith, Gabrick Kyle S, Boop Frederick A, Jaggar Jonathan H
Abstract excerpt
Voltage-dependent L-type Ca(2+) channels (CaV1.2) are the primary Ca(2+) entry pathway in vascular smooth muscle cells (myocytes). CaV1.2 channels control systemic blood pressure and organ blood flow and are pathologically altered in vascular diseases, which modifies vessel contractility. The CaV1.2 distal C-terminus is susceptible to proteolytic cleavage, which yields a truncated CaV1.2 subunit and a cleaved...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.