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Article

Memory T cells persisting in the brain following MCMV infection induce long-term microglial activation via interferon-γ.

Journal of neurovirology - 1 Oct 2011

Mutnal Manohar B, Hu Shuxian, Little Morgan R, Lokensgard James R

Abstract excerpt

Murine cytomegalovirus (MCMV) brain infection stimulates microglial cell-driven proinflammatory chemokine production which precedes the presence of brain-infiltrating systemic immune cells. Here, we show that in response to MCMV brain infection, antigen-specific CD8(+) T cells migrated into the brain and persisted as long-lived memory cells. The role of these persistent T cells in the brain is unclear because...

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Source

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Identifiers

PMID: 21800103
DOI: 10.1007/s13365-011-0042-5
PMCID: PMC3204167

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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