Production of random classes of immunoglobulins in brain tissue during persistent viral infection paralleled by secretion of interleukin-6 (IL-6) but not IL-4, IL-5, and gamma interferon.

doi:10.1128/JVI.65.3.1364-1369.1991

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Article

Production of random classes of immunoglobulins in brain tissue during persistent viral infection paralleled by secretion of interleukin-6 (IL-6) but not IL-4, IL-5, and gamma interferon.

Journal of virology - 1 Mar 1991

Moskophidis D, Frei K, Löhler J, Fontana A, Zinkernagel R M

Abstract excerpt

The activities of cytokines were determined in cerebrospinal fluid (CSF) and serum of mice persistently or intracerebrally acutely infected with lymphocytic choriomeningitis (LCM) virus (LCMV). In contrast to CBA/J (LCMV carrier) mice that responded with low levels of LCMV-specific antibody, high-responder NMRI (carrier) mice showed antibody production by B cells outside of lymphoid organs. The B cells that had...

Topics

Animals
Antibodies, Viral
Antibody Formation
Brain
Immunoglobulins
Interferon-gamma
Interleukin-4
Interleukin-5
Interleukin-6
Lymphocytic Choriomeningitis
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred AKR

Mice, Inbred C57BL

Mice, Inbred CBA

Mice, Inbred DBA

Mice, Inbred Strains

Phenotype

Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 1899893
DOI: 10.1128/JVI.65.3.1364-1369.1991
PMCID: PMC239913

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1899893-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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