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Article

Characterization of novel LncRNA P14AS as a protector of ANRIL through AUF1 binding in human cells

27 Feb 2020

Abstract excerpt

BACKGROUND: The CDKN2A/B locus contains crucial tumor suppressors and a lncRNA gene ANRIL. However, the mechanisms that coordinately regulate their expression levels are not clear. METHODS: Novel RNAs transcribed from the CDKN2A gene were screened by CDKN2A-specific RNA capture deep-sequencing and confirmed by Northern blotting and clone-sequencing. Long non-coding RNA (lncRNA) binding proteins were characterized...

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PMID: 32106863
DOI: 10.1186/s12943-020-01150-4

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