Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.

doi:10.1161/CIRCRESAHA.111.245787

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Article

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.

Circulation research - 16 Sept 2011

Knöll Ralph, Linke Wolfgang A, Zou Peijian, Miocic Snjezana, Kostin Sawa, Buyandelger Byambajav, Ku Ching-Hsin, Neef Stefan, Bug Monika, Schäfer Katrin, Knöll Gudrun, Felkin Leanne E, Wessels Johannes, Toischer Karl, Hagn Franz, Kessler Horst, Didié Michael, Quentin Thomas, Maier Lars S, Teucher Nils, Unsöld Bernhard, Schmidt Albrecht, Birks Emma J, Gunkel Sylvia, Lang Patrick, Granzier Henk, Zimmermann Wolfram-Hubertus, Field Loren J, Faulkner Georgine, Dobbelstein Matthias, Barton Paul J R, Sattler Michael, Wilmanns Matthias, Chien Kenneth R

Abstract excerpt

RATIONALE: Telethonin (also known as titin-cap or t-cap) is a 19-kDa Z-disk protein with a unique β-sheet structure, hypothesized to assemble in a palindromic way with the N-terminal portion of titin and to constitute a signalosome participating in the process of cardiomechanosensing. In addition, a variety of telethonin mutations are associated with the development of several different diseases; however, little...

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PMID: 21799151
DOI: 10.1161/CIRCRESAHA.111.245787
PMCID: PMC3664427

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