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Article

Titin mutations: the fall of Goliath.

Heart failure reviews - 1 Sept 2015

Neiva-Sousa Manuel, Almeida-Coelho João, Falcão-Pires Inês, Leite-Moreira Adelino F

Abstract excerpt

Titin (TTN), the largest protein in the human body, forms powerful elastic filaments along the sarcomere of cardiomyocytes. This multifunctional protein is involved in numerous cellular processes, including sarcomeric assembly, stabilization and mechanosensing. Along physiological sarcomere lengths, TTN is also the most important determinant of the passive tension of cardiac muscle. However, as the giant Goliath...

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Source

Identifiers

PMID: 26024954
DOI: 10.1007/s10741-015-9495-6

Genes

TTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Titin mutations: the fall of Goliath.PMID 26024954Read ↗

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