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Article

Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures

14 Mar 2006

Abstract excerpt

Cardiac muscle is equipped with intricate intrinsic mechanisms to regulate adaptive remodeling. Recent and extensive experimental findings powered by novel strategies for screening protein-protein interactions, improved imaging technologies, and versatile transgenic mouse methodologies reveal that Z disks and titin filaments possess unexpectedly complicated sensory and modulatory mechanisms for signal reception...

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Identifiers

PMID: 16537787
DOI: 10.1152/ajpheart.00816.2005

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