Article
Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.
Cancer research - 15 Jul 2009
Rebbeck Timothy R, Mitra Nandita, Domchek Susan M, Wan Fei, Chuai Shannon, Friebel Tara M, Panossian Saarene, Spurdle Amanda, Chenevix-Trench Georgia, Singer Christian F, Pfeiler Georg, Neuhausen Susan L, Lynch Henry T, Garber Judy E, Weitzel Jeffrey N, Isaacs Claudine, Couch Fergus, Narod Steven A, Rubinstein Wendy S, Tomlinson Gail E, Ganz Patricia A, Olopade Olufunmilayo I, Tung Nadine, Blum Joanne L, Greenberg Roger, Nathanson Katherine L, Daly Mary B
Abstract excerpt
Inherited BRCA1/2 mutations confer elevated ovarian cancer risk. Knowledge of factors that can improve ovarian cancer risk assessment in BRCA1/2 mutation carriers is important because no effective early detection for ovarian cancers exists. A cohort of 1,575 BRCA1 and 856 BRCA2 mutation carriers was used to evaluate haplotypes at ATM, BARD1, BRIP1, CTIP, MRE11, NBS1, RAD50, RAD51, and TOPBP1 in ovarian cancer...
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