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Article

<i>Dickkopf‐3</i> is regulated by the MYCN‐induced miR‐17‐92 cluster in neuroblastoma

27 Jul 2011

Abstract excerpt

Neuroblastoma (NB) is a paediatric tumour with a remarkable diverse clinical behaviour. Approximately half of the high stage aggressive tumours are characterized by MYCN gene amplification but our understanding of the role of MYCN in NB oncogenesis is incomplete. Previous studies have shown that MYCN expression is inversely correlated with expression of Dickkopf-3 (DKK3), a gene encoding an extracellular protein...

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PMID: 21796614
DOI: 10.1002/ijc.26295

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