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Article

p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance

1 Jan 2012

Abstract excerpt

Neuroblastoma is the most common extra-cranial solid tumor of childhood. Despite significant advances, it currently still remains one of the most difficult childhood cancers to cure, with less than 40% of patients with high-risk disease being long-term survivors. MYCN is a proto-oncogene implicated to be directly involved in neuroblastoma development. Amplification of MYCN is associated with rapid tumor...

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Identifiers

PMID: 23226679
DOI: 10.3389/fonc.2012.00173

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