Article
Acquired genomic copy number aberrations and survival in chronic lymphocytic leukemia.
Blood - 15 Sept 2011
Ouillette Peter, Collins Roxane, Shakhan Sajid, Li Jinghui, Peres Edward, Kujawski Lisa, Talpaz Moshe, Kaminski Mark, Li Cheng, Shedden Kerby, Malek Sami N
Abstract excerpt
Genomic aberrations are of predominant importance to the biology and clinical outcome of patients with chronic lymphocytic leukemia (CLL), and FISH-based genomic risk classifications are routinely used in clinical decision making in CLL. One of the known limitations of CLL FISH is the inability to comprehensively interrogate the CLL genome for genomic changes. In an effort at overcoming the existing limitations...
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