Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic alterations in microRNAs in medulloblastomas.

Brain pathology (Zurich, Switzerland) - 1 Mar 2012

Lv Sheng-Qing, Kim Young-Ho, Giulio Fiaschetti, Shalaby Tarek, Nobusawa Sumihito, Yang Hui, Zhou Zheng, Grotzer Michael, Ohgaki Hiroko

Abstract excerpt

MicroRNAs (miRNAs) regulate a variety of cellular processes via the regulation of multiple target genes. We screened 48 medulloblastomas for mutation, deletion and amplification of nine miRNA genes that were selected on the basis of the presence of potential target sequences within the 3'-untranslated region of the MYCC mRNA. Differential PCR revealed deletions in miR-186 (15%), miR-135a-1 (33%), miR-548d-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebellar Neoplasms
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to HEK293 Cells

Share to HeLa Cells

Share to Medulloblastoma

Share to MicroRNAs

Share to Proto-Oncogene Proteins c-myc

Source

Open in PubMed Open full text

Identifiers

PMID: 21793975
DOI: 10.1111/j.1750-3639.2011.00523.x
PMCID: PMC8029025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic alterations in microRNAs in medulloblastomas.PMID 21793975Read ↗

Integrated microRNA Analysis Identifies miR-512-3p as a Potential Biomarker of Poor Outcome in Pediatric MedulloblastomaSemantic proximity Read ↗

MYCN regulates oncogenic MicroRNAs in neuroblastomaSemantic proximity Read ↗

Widespread Dysregulation of MiRNAs by MYCN Amplification and Chromosomal Imbalances in Neuroblastoma: Association of miRNA Expression with SurvivalSemantic proximity Read ↗

MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype-associated genes in medulloblastoma.Semantic proximity Read ↗

miRNA Expression Profiling of the Murine TH-MYCN Neuroblastoma Model Reveals Similarities with Human Tumors and Identifies Novel Candidate MiRNAsSemantic proximity Read ↗

Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway.Semantic proximity Read ↗

High impact of miRNA-4521 on FOXM1 expression in medulloblastomaSemantic proximity Read ↗

Identification of aberrant microRNA expression pattern in pediatric gliomas by microarray.Semantic proximity Read ↗

MicroRNA-542-5p as a novel tumor suppressor in neuroblastomaSemantic proximity Read ↗

Survey of MicroRNA expression in pediatric brain tumorsSemantic proximity Read ↗

The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cellsSemantic proximity Read ↗

A Functional Screen Identifies miR-34a as a Candidate Neuroblastoma Tumor Suppressor GeneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.