Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High impact of miRNA-4521 on FOXM1 expression in medulloblastoma

20 Sept 2019

Abstract excerpt

Medulloblastoma, an embryonal tumor of the cerebellum/fourth ventricle, is one of the most frequent malignant brain tumors in children. Although genetic variants are increasingly used in treatment stratification, survival of high-risk patients, characterized by leptomeningeal dissemination, TP53 mutation or MYC amplification, is still poor. FOXM1, a proliferation-specific oncogenic transcription factor, is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to FOXO transcription factor regulation
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31541075
DOI: 10.1038/s41419-019-1926-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High impact of miRNA-4521 on FOXM1 expression in medulloblastomaPMID 31541075Read ↗

Expression of FoxM1 Is Required for the Proliferation of Medulloblastoma Cells and Indicates Worse Survival of PatientsSemantic proximity Read ↗

Musashi-1 regulates cell cycle and confers resistance to cisplatin treatment in Group 3/4 medulloblastomas cellsSemantic proximity Read ↗

miR-192 suppresses leptomeningeal dissemination of medulloblastoma by modulating cell proliferation and anchoring through the regulation ofDHFR, integrins, andCD47Semantic proximity Read ↗

Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway.Semantic proximity Read ↗

Knockdown of Musashi-1 enhances chemotherapeutic sensitivity and apoptosis in Group 3/4 medulloblastomas cellsSemantic proximity Read ↗

Molecular Determinants of Medulloblastoma Metastasis and Leptomeningeal DisseminationSemantic proximity Read ↗

MicroRNA-1247 inhibits cell proliferation by directly targeting ZNF346 in childhood neuroblastoma.Semantic proximity Read ↗

Integrated microRNA Analysis Identifies miR-512-3p as a Potential Biomarker of Poor Outcome in Pediatric MedulloblastomaSemantic proximity Read ↗

Insights into cerebellar development and medulloblastoma.Semantic proximity Read ↗

Altered MicroRNA Expression Is Associated with Tumor Grade, Molecular Background and Outcome in Childhood Infratentorial EpendymomaSemantic proximity Read ↗

MiR‐449a exerts tumor‐suppressive functions in human glioblastoma by targeting Myc‐associated zinc‐finger proteinSemantic proximity Read ↗

Glioblastoma Multiforme Formation and EMT: Role of FoxM1 Transcription FactorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.