Article
Histone deacetylase inhibition enhances self renewal and cardioprotection by human cord blood-derived CD34 cells.
PloS one - 1 Jan 2011
Burba Ilaria, Colombo Gualtiero I, Staszewsky Lidia Irene, De Simone Marco, Devanna Paolo, Nanni Simona, Avitabile Daniele, Molla Fabiola, Cosentino Simona, Russo Ilaria, De Angelis Noeleen, Soldo Annarita, Biondi Antonella, Gambini Elisa, Gaetano Carlo, Farsetti Antonella, Pompilio Giulio, Latini Roberto, Capogrossi Maurizio C, Pesce Maurizio
Abstract excerpt
BACKGROUND: Use of peripheral blood- or bone marrow-derived progenitors for ischemic heart repair is a feasible option to induce neo-vascularization in ischemic tissues. These cells, named Endothelial Progenitors Cells (EPCs), have been extensively characterized phenotypically and functionally. The clinical efficacy of cardiac repair by EPCs cells remains, however, limited, due to cell autonomous defects as a...
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