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Valproic Acid Decreases Endothelial Colony Forming Cells Differentiation and Induces Endothelial-to-Mesenchymal Transition-like Process.

Stem cell reviews and reports - 1 Apr 2020

Nevo Nathalie, Lecourt Severine, Bièche Ivan, Kucia Magda, Cras Audrey, Blandinieres Adeline, Vacher Sophie, Gendron Nicolas, Guerin Coralie L, Ratajczak Mariusz Z, Smadja David M

Abstract excerpt

Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor is a widely used anticonvulsant drug. VPA is also under clinical evaluation to be employed in anticancer therapy, as an antithrombotic agent or a molecule to be used in the stem cells expansion protocols. Since endothelial colony forming cells (ECFC) has been identified as the human postnatal vasculogenic cells involved in thrombotic disorders and serve...

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PMID: 31898801
DOI: 10.1007/s12015-019-09950-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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