Article
Overexpression of hypoxia-inducible factor-1 alpha improves vasculogenesis-related functions of endothelial progenitor cells.
Microvascular research - 1 May 2016
Kütscher Christian, Lampert Florian M, Kunze Mirjam, Markfeld-Erol Filiz, Stark G Björn, Finkenzeller Günter
Abstract excerpt
Postnatal vasculogenesis is mediated by mobilization of endothelial progenitor cells (EPCs) from bone marrow and homing to ischemic tissues. This feature emphasizes this cell type for cell-based therapies aiming at the improvement of neovascularization in tissue engineering applications and regenerative medicine. In animal models, it was demonstrated that implantation of EPCs from cord blood (cbEPCs) led to the...
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