Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Valproic Acid Increases CXCR4 Expression in Hematopoietic Stem/Progenitor Cells by Chromatin Remodeling

10 Oct 2008

Abstract excerpt

A major limitation of cord blood (CB) hematopoietic stem/progenitor cell (HSPC) transplantation in adult patients is the low cell dose available, which is associated with delayed or failed engraftment. This has prompted intensive research to develop novel strategies to improve HSPC engraftment and reconstitution. The chemokine receptor CXCR4 and its ligand stromal cell-derived factor (SDF)-1alpha play a crucial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine receptors and signaling
Share to Histone Deacetylase Inhibitors Research
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18847317
DOI: 10.1089/scd.2008.0235

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Valproic Acid Increases CXCR4 Expression in Hematopoietic Stem/Progenitor Cells by Chromatin RemodelingPMID 18847317Read ↗

Differential Effects of Epigenetic Modifiers on the Expansion and Maintenance of Human Cord Blood Stem/Progenitor CellsSemantic proximity Read ↗

Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells.Semantic proximity Read ↗

Expansion and preservation of the functional activity of adult hematopoietic stem cells cultured ex vivo with a histone deacetylase inhibitor.Semantic proximity Read ↗

Histone deacetylase inhibitors potently repress CXCR4 chemokine receptor expression and function in acute lymphoblastic leukaemiaSemantic proximity Read ↗

Hypermethylation of CXCR4 promoter in CD34+ cells from patients with primary myelofibrosis.Semantic proximity Read ↗

Histone deacetylase inhibition enhances self renewal and cardioprotection by human cord blood-derived CD34 cells.Semantic proximity Read ↗

Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells.Semantic proximity Read ↗

Sequential Valproic Acid/All- trans Retinoic Acid Treatment Reprograms Differentiation in Refractory and High-Risk Acute Myeloid LeukemiaSemantic proximity Read ↗

[Clinical relevance of chemokine receptor CXCR4].Semantic proximity Read ↗

Valproic Acid Decreases Endothelial Colony Forming Cells Differentiation and Induces Endothelial-to-Mesenchymal Transition-like Process.Semantic proximity Read ↗

The Epigenetic Modifier, Valproic Acid, Enhances Radiation SensitivitySemantic proximity Read ↗

The N-terminal CEBPA mutant in acute myeloid leukemia impairs CXCR4 expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.