Article
Are purified or expanded cord blood-derived CD133+ cells better at improving cardiac function?
Experimental biology and medicine (Maywood, N.J.) - 1 Jan 2010
Senegaglia Alexandra C, Barboza Laura A, Dallagiovanna Bruno, Aita Carlos A M, Hansen Paula, Rebelatto Carmen L K, Aguiar Alessandra M, Miyague Nelson I, Shigunov Patrícia, Barchiki Fabiane, Correa Alejandro, Olandoski Marcia, Krieger Marco A, Brofman Paulo R S
Abstract excerpt
Endothelial progenitor cells (EPCs), which express the CD133 marker, can differentiate into mature endothelial cells (ECs) and create new blood vessels. Normal angiogenesis is unable to repair the injured tissues that result from myocardial infarction (MI). Patients who have high cardiovascular risks have fewer EPCs and their EPCs exhibit greater in vitro senescence. Human umbilical cord blood (HUCB)-derived EPCs...
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