Article
The stringent response is essential for Pseudomonas aeruginosa virulence in the rat lung agar bead and Drosophila melanogaster feeding models of infection.
Infection and immunity - 1 Oct 2011
Vogt Stefanie L, Green Christopher, Stevens Katarzyna M, Day Brad, Erickson David L, Woods Donald E, Storey Douglas G
Abstract excerpt
The stringent response is a regulatory system that allows bacteria to sense and adapt to nutrient-poor environments. The central mediator of the stringent response is the molecule guanosine 3',5'-bispyrophosphate (ppGpp), which is synthesized by the enzymes RelA and SpoT and which is also degraded by SpoT. Our laboratory previously demonstrated that a relA mutant of Pseudomonas aeruginosa, the principal cause of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.