Article
Discrimination of 'driver' and 'passenger' HPV in tonsillar carcinomas by the polymerase chain reaction, chromogenic in situ hybridization, and p16(INK4a) immunohistochemistry.
Head and neck pathology - 1 Dec 2011
Evans Mark Francis, Matthews Alisa, Kandil Dina, Adamson Christine Stewart-Crawford, Trotman Winifred Elizabeth, Cooper Kumarasen
Abstract excerpt
Human papillomavirus (HPV) positive tonsillar squamous cell carcinoma (TSCC) is associated with a favorable clinical outcome. However, the HPV detected in a given tumor may be causal (driver HPV) or an incidental bystander (passenger HPV). There is a need to discriminate these forms of HPV in TSCCs to understand their impact on HPV as a biomarker for use in TSCC patient management. This study has compared the...
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