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Suppression of InsP3Receptor-Mediated Ca2+Signaling Alleviates Mutant Presenilin-Linked Familial Alzheimer's Disease Pathogenesis

14 May 2014

Abstract excerpt

Exaggerated intracellular Ca(2+) signaling is a robust proximal phenotype observed in cells expressing familial Alzheimer's disease (FAD)-causing mutant presenilins (PSs). The mechanisms that underlie this phenotype are controversial and their in vivo relevance for AD pathogenesis is unknown. Here, we used a genetic approach to identify the mechanisms involved and to evaluate their role in the etiology of AD in...

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PMID: 24828645
DOI: 10.1523/jneurosci.5441-13.2014

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