Article
Evidence that erythrocyte DARC-positive phenotype can affect the GVHD occurrence after HLA-identical sibling HSCT.
Transplant immunology - 1 Sept 2011
Sellami Mohamed Hichem, Chaabane Manel, Kaabi Houda, Torjemane Lamia, Ladeb Saloua, Othmane Tarek Ben, Hmida Slama
Abstract excerpt
Chemokine receptors are very important players in the pathogenesis of GVHD. The aim of this study is to test the hypothesis that the lack of expression of the DARC receptor on erythrocytes can affect the GVHD incidence. A total of 105 recipients and their 105 respective sibling donors of HSCs were enrolled in this study. All patients were evaluated for acute and chronic GVHD. The DARC genotyping assay was...
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