Article
Regulation of the human neurotropic virus promoter by JCV-T antigen and HIV-1 tat protein.
Oncogene - 1 Dec 1990
Chowdhury M, Taylor J P, Tada H, Rappaport J, Wong-Staal F, Amini S, Khalili K
Abstract excerpt
We compared the ability of HIV-1 tat protein and JCV T-antigen in inducing transcription from the JCV late promoter, JCVL. A JCVL promoter-chloramphenicol acetyltransferase plasmid (pJCL-CAT) was transfected into human glial cells alone or together with plasmids producing T-antigen and tat protein. CAT enzyme activity obtained from the transfected cells indicated that both JCV T-antigen and HIV-1 tat proteins...
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