Article
Circadian genes and lithium response in bipolar disorders: associations with PPARGC1A (PGC-1α) and RORA.
Genes, brain, and behavior - 1 Sept 2016
Geoffroy P A, Etain B, Lajnef M, Zerdazi E-H, Brichant-Petitjean C, Heilbronner U, Hou L, Degenhardt F, Rietschel M, McMahon F J, Schulze T G, Jamain S, Marie-Claire C, Bellivier F
Abstract excerpt
Preliminary studies suggest that lithium (Li) response might be associated with some circadian gene polymorphisms, we therefore performed a pharmacogenetic study on the core clock genes in two independent samples suffering from bipolar disorder (BD) and thoroughly characterized for their Li response. Two independent Caucasian samples (165 and 58 bipolar patients) treated with Li were selected from samples...
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