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Article

Epigenetic Silencing of Erythropoietin in Human Cancers

1 Jan 2011

Abstract excerpt

The glycoprotein hormone erythropoietin (EPO) is a key regulator in the production of red blood cells. EPO is produced mainly in the embryonic liver and kidney of adults. Other organs are also known to express varying amounts of EPO. In our study, we have analyzed the epigenetic regulation of EPO in human cancer cell lines by DNA methylation assays, chromatin immunoprecipitation, RT-PCR, and promoter analysis...

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PMID: 21779481
DOI: 10.1177/1947601911405043

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