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Paradoxical Role of DNA Methylation in Activation of FoxA2 Gene Expression during Endoderm Development

12 Jul 2014

Abstract excerpt

The transcription factor FoxA2 is a master regulator of endoderm development and pancreatic beta cell gene expression. To elucidate the mechanisms underlying the activation of the FoxA2 gene during differentiation, we have compared the epigenetic status of undifferentiated human embryonic stem cells (hESCs), hESC-derived early endoderm stage cells (CXCR4+ cells), and pancreatic islet cells. Unexpectedly, a CpG...

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PMID: 25016019
DOI: 10.1074/jbc.m114.573469

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