DNA methylation represses the expression of the human erythropoietin gene by two different mechanisms

Abstract excerpt

The human erythropoietin gene is expressed predominantly in the kidney and liver in response to hypoxia. Although the signaling cascade for hypoxia is present in many different cell types, the expression of erythropoietin is restricted to only a few tissues. The authors show that the promoter and 5'-untranslated region (5'-UTR) of the erythropoietin gene comprise a CpG island and that methylation of the CpG...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related gene regulation
• Share to Epigenetics and DNA Methylation
• Share to Erythropoietin and Anemia Treatment