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<i><i>ANGPT2</i></i>promoter methylation is strongly associated with gene expression and prognosis in chronic lymphocytic leukemia

26 Jun 2013

Abstract excerpt

Increasing evidence suggests a key role for angiopoietin-2 (ANGPT2) in influencing the aggressiveness of chronic lymphocytic leukemia (CLL). In the presence of vascular endothelial growth factor (VEGF), ANGPT2 causes vessel destabilization leading to neoangiogenesis. Accordingly, high expression levels of ANGPT2 and high degree of angiogenesis have consistently been associated with poor prognosis in CLL; however,...

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PMID: 23803577
DOI: 10.4161/epi.24947

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