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Article

Are Sema5a mutant mice a good model of autism? A behavioral analysis of sensory systems, emotionality and cognition.

Behavioural brain research - 20 Nov 2011

Gunn Rhian K, Huentelman Matthew J, Brown Richard E

Abstract excerpt

Semaphorin 5A (Sema5A) expression is reduced in the brain of individuals with autism, thus mice with reduced Sema5A levels may serve as a model of this neurodevelopmental disorder. We tested male and female Sema5a knockout mice (B6.129P2SEMA5A(<)™(1DGEN>)/J) and C57BL/6J controls for emotionality, visual ability, prepulse inhibition, motor learning and cognition. Overall, there were only two genotype differences...

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Source

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Identifiers

PMID: 21777623
DOI: 10.1016/j.bbr.2011.07.008
PMCID: PMC3170441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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