Article
Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology.
PloS one - 1 Jan 2011
Rünker Annette E, O'Tuathaigh Colm, Dunleavy Mark, Morris Derek W, Little Graham E, Corvin Aiden P, Gill Michael, Henshall David C, Waddington John L, Mitchell Kevin J
Abstract excerpt
Psychiatric disorders such as schizophrenia and autism are characterised by cellular disorganisation and dysconnectivity across the brain and can be caused by mutations in genes that control neurodevelopmental processes. To examine how neurodevelopmental defects can affect brain function and behaviour, we have comprehensively investigated the consequences of mutation of one such gene, Semaphorin-6A, on cellular...
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