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Article

Modulating Microtubule Stability Enhances the Cytotoxic Response of Cancer Cells to Paclitaxel

20 Jul 2011

Abstract excerpt

The extracellular matrix protein TGFBI enhances the cytotoxic response of cancer cells to paclitaxel by affecting integrin signals that stabilize microtubules. Extending the implications of this knowledge, we tested the more general hypothesis that cancer cell signals which increase microtubule stability before exposure to paclitaxel may increase its ability to stabilize microtubules and thereby enhance its...

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PMID: 21775522
DOI: 10.1158/0008-5472.can-11-0025

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